CORAL: model for no observed adverse effect level (NOAEL)
نویسندگان
چکیده
منابع مشابه
Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL).
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In the first experiment 0.1 mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin-releasing hormone (GnRH) induced testosterone s...
متن کاملAcute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determi...
متن کاملA proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties.
OBJECTIVES Both environmental and occupational exposure limits are based on the no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL) or benchmark dose (BMD) deriving from epidemiological and experimental studies. The aim of this study is to investigate to what extent the NOAEL values for organic compounds responsible for liver toxicity calculated based on their...
متن کاملStatistical issues on the no-observed-adverse-effect level in categorical response.
The determination of the value of the no-observed-adverse-effect level (NOAEL) when observed responses can be categorized by severity (categorical data) and sample sizes are small is discussed. The common situation of only two categories, where only the presence or absence of an effect is observed, is addressed first (dichotomous data). Three tests for dichotomous data are critically examined, ...
متن کاملWhat Level of Effect Is a No Observed Effect?
The no observed effect concentration (NOEC) is currently a major summary statistic in ecotoxicity testing. Its use is heavily criticized, partly because it is a poor estimator of ‘‘safe’’ chemical concentrations. In this short communication, we review the limited information available on the percentage effect that corresponds with the NOEC, a value designated the ECNOEC, and calculate ECNOEC va...
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ژورنال
عنوان ژورنال: Molecular Diversity
سال: 2015
ISSN: 1381-1991,1573-501X
DOI: 10.1007/s11030-015-9587-1